Active Ingredients: Ciprofloxacin
One prospective study followed 29 pediatric patients with cystic fibrosis who had received 7—10 days of antibiotic treatment; 14 were treated with ciprofloxacin or ofloxacin, and 15 were treated with other standard cystic fibrosis antibiotic regimens.
Because children with cystic fibrosis are predisposed to joint abnormalities, this study failed to demonstrate that fluoroquinolone was associated with any additional risk of joint damage. The fluoroquinolone-induced irreversible articular cartilage damage observed in large weight-bearing joints of juvenile animals evolves rapidly, within days.
However, irreversible fluoroquinolone-induced cartilage toxicity was not demonstrated during treatment and follow-up time range. Such a finding should indicate the problems with extrapolating from animal data to humans and provide evidence, at the very least, that if fluoroquinolones do have adverse effects on the cartilage of children and adolescents, those effects are minimal compared with those found among animals.
Clinical research studies with adverse events as end points.
A variety of adverse events associated with fluoroquinolone use have been described among pediatric and adolescent patients table 2. The most common complaints were gastrointestinal e.
All of the adverse events were self-limited. Six of 22 studies failed to detect any fluoroquinolone-associated adverse events among 118 pediatric and adolescent subjects.What is minocycline.
Table 2 Studies reporting adverse events associated with fluoroquinolone use among adolescents and children. Table 2 Open in new tab Download slide Studies reporting adverse events associated with fluoroquinolone use among adolescents and children.
Musculoskeletal complaints occurred more frequently among pediatric and adolescent patients than among adults. Table 3 Adverse events associated with fluoroquinolone use among adolescents and children as reported in the literature and by the Physicians Desk Reference PDR.
Table 3 Open in new tab Download slide Adverse events associated with fluoroquinolone use among adolescents and children as reported in the literature and by the Physicians Desk Reference PDR.
Case reports of adverse events.
Various reported pediatric and adolescent fluoroquinolone-associated adverse events, such as anaphylactic reaction, dystonic reaction, sleep disturbance, arthralgias, and hallucinations, have also been reported to occur in fluoroquinolone-treated adults table 4.
Pristinamycin IIA binds to the 50 S subunit of the bacterial ribosome and induces a conformational change to enhance binding of IA, which is irreversible and arrests protein synthesis.
This agent has a favorable toxicity profile, is approved for use in pregnancy, and has a broad spectrum of in vitro activity against most gram-positive cocci and Clostridium, Haemophilus, Neisseria, Ureaplasma, and Mycoplasma species.
In vitro data show favorable MICs for pristinamycin in both macrolide- and fluoroquinolone-resistant M. In vitro studies have also had that solithromycin is active against Chlamydia trachomatis and N.
Minocin …. Among the Centers for Disease Control and Prevention CDC -recommended single-dose gonorrhea treatment regimens, dose of ciprofloxacin to treat uncomplicated gonorrhea the cost of other CDC-recommended oral treatment.