Active Ingredients: Ciprofloxacin
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Figure 1. ATAD 3 is used as loading reference.
Note that the used polyclonal antibodies might detect mouse and human proteins with different efficiencies.
The pellet fraction after digitonin treatment contains inner membrane-associated proteins and nucleoids, while the supernatant fraction contains soluble nucleoids and proteins without membrane-association.
Also the mitochondrial topoisomerases Top 3 a and Top 1 mt partially co-localize with this fraction, but a larger proportion is found in other fractions. To analyse the mitochondrial role of the two Top 2 isoforms, we investigated with which pools of mtDNA the enzymes are interacting.
He has held the chair for Drug Design at the University of Groningen since. His interests are centered on MCR chemistry and its application to problems in drug discovery.
His special focus is centered on the question of how to leverage the huge MCR space.
Thus, he is working on MCR centered pharmacophore methods, structure-based drug design, and MCR-centered fragment-based drug design methods and extreme miniaturization to library synthesis.
He has applied for more than 30 patents. His long-term vision is to bring a novel drug to patients in an indicated area of unmet medical needs.
Introduction Jump To Tetrazoles belong to the class of twice unsaturated five-membered ring aromatic heterocycles, consisting of one carbon and four nitrogen atoms.
They do not exist in nature.
Interestingly, they have the highest number of nitrogen atoms among the stable heterocycles because pentazoles are highly explosive compounds even at low temperature. Bladin in 1885 at the University of Upsala.